I can't think of one specific thing so here are a few things...
- Designing the site to work in Firefox and then modifying to get IE to behave afterwards. Usually if it works in Firefox it will work in other browsers, though IE has some annoying quirks.
- Controlling layout via CSS rather than tables makes things easier for screen readers.
- Avoid designing an entire site in flash, or atleast provide an alternative for those not using flash.
- Try to provide a javascript free method to navigate the site (eg. site map link).
- Try to make it relatively easy to distinguish hyperlinks from normal text, and similarly text from background, bearing in mind colour-blind users.
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