Setup of linux as well as windows mirrored dedicated servers, load balancer clusters are completely different. For e.g. on a windows dedicated server, if you need a cluster setup, you can always have SAN - Storage Area Network which will store your data and it will not be stored on the servers.
When one server is active, it will retrieve data from SAN and when server1 goes down and switches over to server2 retrieving data from the same SAN. In simple language, centralized data storage and in this case, you will need to backup SAN which is normally not required. Plesk does not support cluster setup in this case. However, we have figured out a solution where plesk can run from both the servers.
With linux mirrored dedicated server hosting solutions, replication of data between two servers is not a problem at all and can easily be syncd with scripts running between both the servers and Rsync for backup. That's just a basic about them. If you have cPanel - WHM installed on the servers, you can take backup from the servers easily.
However, if terms of data backup to a remote location. This can be done through Rsync technology which will automatically take backups at regular intervals as per your requirement.
Please be advised that it is possible to take manual backups from the server. However, if you are new to the server management, i would suggest that you should contact your hosting provider to assist you with the backup and restoration process.
Regards,
Shane Phillips